The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.
Isopenicillin N synthase (IPNS) converts its linear tripeptide substrate δ-L-α-aminoadipoyl-L-cysteinyl-D-valine (ACV) to bicyclic isopenicillin N (IPN), the key step in penicillin biosynthesis. Solution-phase incubation experiments have shown that IPNS will accept and oxidise a diverse array of sub...
Hoofdauteurs: | , , , , |
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Formaat: | Journal article |
Taal: | English |
Gepubliceerd in: |
2013
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