The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.

Isopenicillin N synthase (IPNS) converts its linear tripeptide substrate δ-L-α-aminoadipoyl-L-cysteinyl-D-valine (ACV) to bicyclic isopenicillin N (IPN), the key step in penicillin biosynthesis. Solution-phase incubation experiments have shown that IPNS will accept and oxidise a diverse array of sub...

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Bibliografische gegevens
Hoofdauteurs: Daruzzaman, A, Clifton, I, Adlington, R, Baldwin, J, Rutledge, P
Formaat: Journal article
Taal:English
Gepubliceerd in: 2013