Reductive hydroxymethylation of 4‐heteroarylpyridines

The activation of pyridinium salts with electron‐withdrawing heterocycles enables an iridium‐catalyzed reductive hydroxymethylation reaction to proceed smoothly, facilitating the preparation of useful 3D heteroaryl‐substituted functionalized piperidines. The methodology is used to prepare 3‐hydroxym...

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Detalles Bibliográficos
Main Authors: Hepburn, HB, Donohoe, TJ
Formato: Journal article
Idioma:English
Publicado: Wiley 2020