Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes
AlkB homologue 5 (ALKBH5) is a ferrous iron and 2-oxoglutarate dependent oxygenase that demethylates RNA <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A), a post-transcriptional RNA modification with an emerging set of regulatory roles. Along with the fat mas...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2022
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