Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol...

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প্রধান লেখক:	Postmus, I, Trompet, S, Deshmukh, H, Barnes, MR, Li, X, Warren, H, Chasman, D, Zhou, K, Arsenault, B, Donnelly, L, Wiggins, K, Avery, C, Griffin, P, Feng, Q, Taylor, K, Li, G, Evans, D, Smith, A, De Keyser, C, Johnson, A, De Craen, A, Stott, D, Buckley, B, Ford, I, Westendorp, R, Slagboom, P, Sattar, N, Munroe, P, Sever, P, Poulter, N, Stanton, A, Shields, D, O'Brien, E, Shaw-Hawkins, S, Chen, Y, Nickerson, D, Smith, J, Dubé, M, Boekholdt, S, Hovingh, G, Kastelein, J, McKeigue, P, Betteridge, J, Neil, A, Durrington, P, Doney, A, Carr, F, Morris, A, McCarthy, M, Groop, L, Ahlqvist, E, Bis, J, Rice, K, Smith, N, Lumley, T, Whitsel, E, Stürmer, T, Boerwinkle, E, Ngwa, J, O'Donnell, C, Vasan, R, Wei, W, Wilke, R, Liu, C, Sun, F, Guo, X, Heckbert, SR, Post, W, Sotoodehnia, N, Arnold, A, Stafford, J, Ding, J, Herrington, D, Kritchevsky, S, Eiriksdottir, G, Launer, L, Harris, T, Chu, A, Giulianini, F, Macfadyen, J, Barratt, B, Nyberg, F, Stricker, B, Uitterlinden, A, Hofman, A, Rivadeneira, F, Emilsson, V, Franco, O, Ridker, P, Gudnason, V, Liu, Y, Denny, J, Ballantyne, C, Rotter, J, Adrienne Cupples, L, Psaty, B, Palmer, C, Tardif, J, Colhoun, H, Hitman, G, Krauss, R, Wouter Jukema, J, Caulfield, M, Wellcome Trust Case Control Consortium
বিন্যাস:	Journal article
ভাষা:	English
প্রকাশিত:	Springer Nature 2014

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

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