Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol...

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Bibliographic Details
Main Authors: Postmus, I, Trompet, S, Deshmukh, H, Barnes, MR, Li, X, Warren, H, Chasman, D, Zhou, K, Arsenault, B, Donnelly, L, Wiggins, K, Avery, C, Griffin, P, Feng, Q, Taylor, K, Li, G, Evans, D, Smith, A, De Keyser, C, Johnson, A, De Craen, A, Stott, D, Buckley, B, Ford, I, Westendorp, R, Slagboom, P, Sattar, N, Munroe, P, Sever, P, Poulter, N, Stanton, A, Shields, D, O'Brien, E, Shaw-Hawkins, S, Chen, Y, Nickerson, D, Smith, J, Dubé, M, Boekholdt, S, Hovingh, G, Kastelein, J, McKeigue, P, Betteridge, J, Neil, A, Durrington, P, Doney, A, Carr, F, Morris, A, McCarthy, M, Groop, L, Ahlqvist, E, Bis, J, Rice, K, Smith, N, Lumley, T, Whitsel, E, Stürmer, T, Boerwinkle, E, Ngwa, J, O'Donnell, C, Vasan, R, Wei, W, Wilke, R, Liu, C, Sun, F, Guo, X, Heckbert, SR, Post, W, Sotoodehnia, N, Arnold, A, Stafford, J, Ding, J, Herrington, D, Kritchevsky, S, Eiriksdottir, G, Launer, L, Harris, T, Chu, A, Giulianini, F, Macfadyen, J, Barratt, B, Nyberg, F, Stricker, B, Uitterlinden, A, Hofman, A, Rivadeneira, F, Emilsson, V, Franco, O, Ridker, P, Gudnason, V, Liu, Y, Denny, J, Ballantyne, C, Rotter, J, Adrienne Cupples, L, Psaty, B, Palmer, C, Tardif, J, Colhoun, H, Hitman, G, Krauss, R, Wouter Jukema, J, Caulfield, M, Wellcome Trust Case Control Consortium
Format: Journal article
Language:English
Published: Springer Nature 2014

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