Genetic modification of primary human B cells generates translationally-relevant models of high-grade lymphoma

Abstract Sequencing studies of Diffuse Large B Cell Lymphoma (DLBCL) have identified hundreds of recurrently altered genes. However, it remains largely unknown whether and how these mutations may contribute to lymphomagenesis, either individually or in combination. Existing strategies to address thi...

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Dettagli Bibliografici
Autori principali: Caeser, R, Di Re, M, Krupka, J, Gao, J, Lara-Chica, M, Dias, JML, Cooke, S, Fenner, R, Usheva, Z, Runge, H, Beer, P, Eldaly, H, Pak, H-K, Park, C-S, Vassiliou, GS, Huntly, BJP, Mupo, A, Bashford-Rogers, RJM, Hodson, D
Natura: Journal article
Lingua:English
Pubblicazione: Nature Research 2019