Reappraisal of the historical selective pressures for the CCR5-Delta32 mutation.
HIV strains are unable to enter macrophages that carry the CCR5-Delta32 deletion; the average frequency of this allele is 10% in European populations. A mathematical model based on the changing demography of Europe from 1000 to 1800 AD demonstrates how plague epidemics, 1347 to 1670, could have prov...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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