Quinazolinone-based anticancer agents: synthesis, anti-proliferative SAR, anti-tubulin activity and tubulin co-crystal structure
Quinazolinone-based anti-cancer agents were designed, decorated with functional groups from a 2-methoxyestradiol-based microtubule disruptor series, incorporating the aryl sulfamate motif of steroid sulfatase (STS) inhibitors. The steroidal AB-ring system was mimicked, favoring conformations with an...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
American Chemical Society
2017
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