Small-molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling
RIPK2 mediates inflammatory signaling by the bacteria-sensing receptors NOD1 and NOD2. Kinase inhibitors targeting RIPK2 are a proposed strategy to ameliorate NOD-mediated pathologies. Here, we reveal that RIPK2 kinase activity is dispensable for NOD2 inflammatory signaling and show that RIPK2 inhib...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
EMBO Press
2018
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