Mechanisms underlying the endogenous neuroprotection of hamartin in ischaemic stroke

<p>Introduction: Hamartin has been shown to mediate the endogenous resistance of Cornu Ammonis 3 (CA3) neurons to ischaemia. Proposed mechanisms concern the inhibition of mammalian target of rapamycin (mTOR) which could promote productive autophagy and prevent endoplasmic reticulum (ER) stress...