Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.

Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.

AIMS/HYPOTHESIS: Stearoyl-CoA desaturase (SCD) is emerging as a key regulator of lipid and carbohydrate metabolism. Scd-null mice display a beneficial metabolic phenotype characterised by resistance to obesity, diabetes and hyperlipidaemia. The human homologue, SCD, maps to a region of chromosome 10...

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Bibliographic Details
Main Authors: Liew, C, Groves, C, Wiltshire, S, Zeggini, E, Frayling, T, Owen, K, Walker, M, Hitman, G, Levy, J, O'rahilly, S, Hattersley, A, Johnston, D, McCarthy, M
Format: Journal article
Language:English
Published: 2004

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