Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.

During HIV/SIV infection, there is widespread programmed cell death in infected and, perhaps more importantly, uninfected cells. Much of this apoptosis is mediated by Fas-Fas ligand (FasL) interactions. Previously we demonstrated in macaques that induction of FasL expression and apoptotic cell death...

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Bibliographic Details
Main Authors: Xu, X, Laffert, B, Screaton, G, Kraft, M, Wolf, D, Kolanus, W, Mongkolsapay, J, Mcmichael, A, Baur, A
Format: Journal article
Language:English
Published: 1999