When are randomised trials unnecessary? Picking signal from noise.

Although randomised trials are widely accepted as the ideal way of obtaining unbiased estimates of treatment effects, some treatments have dramatic effects that are highly unlikely to reflect inadequately controlled biases. We compiled a list of historical examples of such effects and identified the...

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Bibliographic Details
Main Authors: Glasziou, P, Chalmers, I, Rawlins, M, McCulloch, P
Format: Journal article
Language:English
Published: 2007