Synthetic lethality between PAXX and XLF in mammalian development
PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf−/− mice, Paxx−/− mice are viable, grow normally, and are fertile but show mild radiosensitivity. Strikingly, while P...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
Cold Spring Harbor Laboratory Press
2016
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