Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

<strong>Aims/hypothesis</strong> Pancreatic beta cells secrete insulin to maintain glucose homeostasis, and beta cell failure is a hallmark of type 2 diabetes. Glucose triggers insulin secretion in beta cells via oxidative mitochondrial pathways. However, it also feeds mitochondrial anap...

Podrobná bibliografie
Hlavní autoři:	Cantley, J, Davenport, A, Vetterli, L, Nemes, N, Whitworth, P, Boslem, E, Thai, L, Mellett, N, Meikle, P, Hoehn, K, James, D, Biden, T
Médium:	Journal article
Jazyk:	English
Vydáno:	Springer Verlag 2018

Podobné jednotky

Acetyl-CoA carboxylase-1 is a critical regulator of beta cell size and proliferation
Autor: Cantley, J, a další
Vydáno: (2013)

Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses.
Autor: Jang Eun Lee, a další
Vydáno: (2015-01-01)

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells.
Autor: Pearson, G, a další
Vydáno: (2014)

Chemical Genetics of Acetyl-CoA Carboxylases
Autor: Xuyu Zu, a další
Vydáno: (2013-01-01)

Platelet Acetyl-CoA Carboxylase Phosphorylation
Autor: Shakeel Kautbally, MD, a další
Vydáno: (2019-09-01)

Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion
Autor: Anna Veprik, a další
Vydáno: (2022-03-01)

Identification of methylation pattern in the partial promoter of acetyl CoA carboxylase beta (ACACB) gene in White Leghorn line
Autor: C H SHIVAPRASAD, a další
Vydáno: (2023-07-01)

Purification of Native Acetyl CoA Carboxylase From Mammalian Cells
Autor: Yaxue Sun, a další
Vydáno: (2025-02-01)

The dynamic organization of fungal acetyl-CoA carboxylase
Autor: Moritz Hunkeler, a další
Vydáno: (2016-04-01)

Inhibition of rat liver acetyl CoA carboxylase by chloride
Autor: J B Allred, a další
Vydáno: (1980-05-01)

Deletion of the Cited2 gene in beta cells causes impaired insulin secretion and glucose intolerance in mice
Autor: Cantley, J, a další
Vydáno: (2011)

Dynamics of the Degradation of Acetyl-CoA Carboxylase Herbicides in Vegetables
Autor: Miroslav Jursík, a další
Vydáno: (2021-02-01)

Targeting acetyl-CoA carboxylase 1 for cancer therapy
Autor: Yong Yu, a další
Vydáno: (2023-02-01)

Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase.
Autor: Erica C Larson, a další
Vydáno: (2020-01-01)

The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma
Autor: Kun Li, a další
Vydáno: (2019-06-01)

A new method for the isolation of rat liver acetyl-CoA carboxylase.
Autor: L A Witters, a další
Vydáno: (1981-02-01)

Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo.
Autor: Cantley, J, a další
Vydáno: (2011)

Complete inhibition of liver acetyl-CoA carboxylase activity is required to exacerbate liver tumorigenesis in mice treated with diethylnitrosamine
Autor: Riya Shrestha, a další
Vydáno: (2024-11-01)

Plant acetyl-CoA carboxylase: The homomeric form and the heteromeric form
Autor: Dilawar Niazi, a další
Vydáno: (2025-01-01)

Activation of hepatic acetyl-CoA carboxylase by S-nitrosylation in response to diet
Autor: Nicholas M. Venetos, a další
Vydáno: (2024-05-01)

Alternative polyadenylation regulates acetyl-CoA carboxylase function in peanut
Autor: Zhenying Peng, a další
Vydáno: (2023-10-01)

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program
Autor: Adilson Guilherme, a další
Vydáno: (2023-05-01)

Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells
Autor: S. Fediuc, a další
Vydáno: (2006-02-01)

Generation of isogenic Propionyl-CoA carboxylase beta subunit (PCCB) deficient induced pluripotent stem cell lines
Autor: Behshad Pournasr, a další
Vydáno: (2020-10-01)

Overexpression of acetyl-CoA carboxylase in Aspergillus terreus to increase lovastatin production
Autor: Hasan, Hanan, a další
Vydáno: (2018)

Sequences of acetyl CoA carboxylase promoter for tumour necrosis factor action
Autor: Keerang Park, a další
Vydáno: (1993-01-01)

Biochemical and structural characterization of quizalofop-resistant wheat acetyl-CoA carboxylase
Autor: Raven Bough, a další
Vydáno: (2022-01-01)

Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis.
Autor: Kristen E N Scott, a další
Vydáno: (2012-01-01)

Emerging possibilities in the advancement of herbicides to combat acetyl-CoA carboxylase inhibitor resistance
Autor: Bikash Kumar Rajak, a další
Vydáno: (2023-07-01)

Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalities
Autor: Chieh-Ting Fang, a další
Vydáno: (2023-01-01)

Interaction of acetyl-CoA carboxylase enzyme inhibiting herbicides with auxin herbicides on ryegrass
Autor: Rubens Antonio Polito, a další
Vydáno: (2021-04-01)

Cover 3 - Acetyl-CoA Carboxylase Inhibition Has Multimodal Effects in NASH
Vydáno: (2020-01-01)

Regulation of human Th9 cell differentiation by lipid modulators targeting PPAR-γ and acetyl-CoA-carboxylase 1
Autor: Swetha Peesari, a další
Vydáno: (2024-12-01)

Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model SystemsSummary
Autor: Trenton T. Ross, a další
Vydáno: (2020-01-01)

Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity
Autor: Jiejie Shen, a další
Vydáno: (2024-05-01)

A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens
Autor: Gemma L. Pearson, a další
Vydáno: (2016-06-01)

A multifunctional acetyl-CoA carboxylase gene confers freesing tolerance in arabidopsis thaliana
Autor: Amid, Azura, a další
Vydáno: (2009)

Mechanism of inhibiting acetyl CoA carboxylase 2 to improve cardiac dysfunction in septic mice
Autor: DU Yunxia, a další
Vydáno: (2024-12-01)

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis
Autor: Sandra Galic, a další
Vydáno: (2018-02-01)

Underlying resistance mechanisms in the Cynosurus echinatus biotype to acetyl CoA carboxylase-inhibiting herbicides
Autor: Pablo eFernández, a další
Vydáno: (2016-04-01)