Characterisation of DNA polymerase δ exonuclease domain mutations associated with cancer predisposition using fission yeast

Characterisation of DNA polymerase δ exonuclease domain mutations associated with cancer predisposition using fission yeast

<p>Heterozygous germline exonuclease/proofreading domain mutations (EDMs) in DNA polymerase delta (Pol δ) are linked predominantly to colorectal and endometrial cancers with microsatellite stability (MSS), such as POLD1 S478N. Pol δ synthesises the lagging strand during DNA replication and par...

Podrobná bibliografie
Hlavní autor:	Toumazou, SI
Další autoři:	Kearsey, S
Médium:	Diplomová práce
Jazyk:	English
Vydáno:	2021
Témata:	Genetics Schizosaccharomyces pombe Cancer

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