Characterisation of DNA polymerase δ exonuclease domain mutations associated with cancer predisposition using fission yeast

Characterisation of DNA polymerase δ exonuclease domain mutations associated with cancer predisposition using fission yeast

<p>Heterozygous germline exonuclease/proofreading domain mutations (EDMs) in DNA polymerase delta (Pol δ) are linked predominantly to colorectal and endometrial cancers with microsatellite stability (MSS), such as POLD1 S478N. Pol δ synthesises the lagging strand during DNA replication and par...

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Chi tiết về thư mục
Tác giả chính:	Toumazou, SI
Tác giả khác:	Kearsey, S
Định dạng:	Luận văn
Ngôn ngữ:	English
Được phát hành:	2021
Những chủ đề:	Genetics Schizosaccharomyces pombe Cancer

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