Characterisation of DNA polymerase δ exonuclease domain mutations associated with cancer predisposition using fission yeast

Characterisation of DNA polymerase δ exonuclease domain mutations associated with cancer predisposition using fission yeast

<p>Heterozygous germline exonuclease/proofreading domain mutations (EDMs) in DNA polymerase delta (Pol δ) are linked predominantly to colorectal and endometrial cancers with microsatellite stability (MSS), such as POLD1 S478N. Pol δ synthesises the lagging strand during DNA replication and par...

書目詳細資料
主要作者:	Toumazou, SI
其他作者:	Kearsey, S
格式:	Thesis
語言:	English
出版:	2021
主題:	Genetics Schizosaccharomyces pombe Cancer

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