Characterisation of DNA polymerase δ exonuclease domain mutations associated with cancer predisposition using fission yeast
<p>Heterozygous germline exonuclease/proofreading domain mutations (EDMs) in DNA polymerase delta (Pol δ) are linked predominantly to colorectal and endometrial cancers with microsatellite stability (MSS), such as POLD1 S478N. Pol δ synthesises the lagging strand during DNA replication and par...
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| Format: | Thèse |
| Langue: | English |
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2021
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