Loss of heterozygosity analysis: practically and conceptually flawed?
The Knudson "two-hit" hypothesis has provided the rationale for studies that aim to identify tumor-suppressor genes by mapping regions of allelic loss (loss of heterozygosity, LOH). Although LOH has been found in practically all types of tumors, very few such projects have been successful...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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