Quality of isolated pig islets is improved using perfluorohexyloctane for pancreas storage in a split lobe model.

Quality of isolated pig islets is improved using perfluorohexyloctane for pancreas storage in a split lobe model.

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Pancreas transportation between donor center and islet production facility is frequently associated with prolonged ischemia impairing islet isolation and transplantation outcomes. It is foreseeable that shipment of pig pancreases from distant centralized biosecure breeding facilities to institutes t...

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Manylion Llyfryddiaeth
Prif Awduron:	Brandhorst, H, Iken, M, Scott, W, Papas, K, Theisinger, B, Johnson, P, Korsgren, O, Brandhorst, D
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2013

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Quality of Isolated Pig Islets is Improved Using Perfluorohexyloctane for Pancreas Storage in a Split Lobe Model
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Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation.
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Degraded collagenase deteriorates islet viability.
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Prevention of early islet graft failure by selective inducible nitric oxide synthase inhibitors after pig to nude rat intraportal islet transplantation.
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The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors
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The importance of tryptic-like activity in purified enzyme blends for efficient islet isolation.
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High seeding density induces local hypoxia and triggers a proinflammatory response in isolated human islets
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Heat-exposed pig islets are protected from inflammatory mediators but express proapoptotic proteins.
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Influence of neutral protease activity on human islet isolation outcome.
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Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets.
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Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets
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High-dosed nicotinamide decreases early graft failure after pig to nude rat intraportal islet transplantation.
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