Quality of isolated pig islets is improved using perfluorohexyloctane for pancreas storage in a split lobe model.

Quality of isolated pig islets is improved using perfluorohexyloctane for pancreas storage in a split lobe model.

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Pancreas transportation between donor center and islet production facility is frequently associated with prolonged ischemia impairing islet isolation and transplantation outcomes. It is foreseeable that shipment of pig pancreases from distant centralized biosecure breeding facilities to institutes t...

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Bibliografiske detaljer
Main Authors:	Brandhorst, H, Iken, M, Scott, W, Papas, K, Theisinger, B, Johnson, P, Korsgren, O, Brandhorst, D
Format:	Journal article
Sprog:	English
Udgivet:	2013

Lignende værker

Quality of Isolated Pig Islets is Improved Using Perfluorohexyloctane for Pancreas Storage in a Split Lobe Model
af: Brandhorst, H, et al.
Udgivet: (2013)

Perfluorohexyloctane improves long-term storage of rat pancreata for subsequent islet isolation.
af: Brandhorst, H, et al.
Udgivet: (2009)

Evaluation of perfluorohexyloctane/polydimethylsiloxane for pancreas preservation for clinical islet isolation and transplantation
af: Sthle, M, et al.
Udgivet: (2016)

Pig pancreas oxygenation at 20 degrees C increases islet ATP generation but deteriorates islet function.
af: Iken, M, et al.
Udgivet: (2009)

Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia.
af: Brandhorst, D, et al.
Udgivet: (2006)

Long-term preservation of the pig pancreas by a one-layer method for successful islet isolation.
af: Brandhorst, D, et al.
Udgivet: (2005)

Successful pancreas preservation by a perfluorocarbon-based one-layer method for subsequent pig islet isolation.
af: Brandhorst, D, et al.
Udgivet: (2005)

Adaption of neutral protease activity for islet isolation from the long-term two-layer method-stored pig pancreas.
af: Brandhorst, D, et al.
Udgivet: (2005)

Influence of collagenase loading on long-term preservation of pig pancreas by the two-layer method for subsequent islet isolation.
af: Brandhorst, D, et al.
Udgivet: (2005)

Pancreatic islets: methods for isolation and purification of juvenile and adult pig islets
af: Brandhorst, H, et al.
Udgivet: (2016)

Using HTK for prolonged pancreas preservation prior to human islet isolation
af: Caballero-Corbalán, J, et al.
Udgivet: (2012)

Using HTK for prolonged pancreas preservation prior to human islet isolation.
af: Caballero-Corbalán, J, et al.
Udgivet: (2012)

Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators
af: Brandhorst, H, et al.
Udgivet: (2016)

A new oxygen carrier for improved long-term storage of human pancreata before islet isolation.
af: Brandhorst, H, et al.
Udgivet: (2010)

Comparison of neutral proteases and collagenase class I as essential enzymes for human islet isolation
af: Brandhorst, H, et al.
Udgivet: (2015)

Comparison of Clostripain and Neutral Protease as Supplementary Enzymes for Human Islet Isolation
af: Brandhorst, H, et al.
Udgivet: (2018)

Quantifying the effects of different neutral proteases on human islet integrity
af: Brandhorst, H, et al.
Udgivet: (2018)

The ratio between collagenase class I and class II influences the efficient islet release from the rat pancreas.
af: Brandhorst, H, et al.
Udgivet: (2008)

Pretransplant induction of HSP-70 in isolated adult pig islets decreases early islet xenograft survival.
af: Brandhorst, D, et al.
Udgivet: (2000)

Solubilized pancreatic extracellular matrix from juvenile pigs protects isolated human islets from hypoxia-induced damage: a viable option for clinical islet transplantation
af: Brandhorst, H, et al.
Udgivet: (2023)

Effect of stable glutamine compounds on porcine islet culture.
af: Brandhorst, H, et al.
Udgivet: (2005)

Enzyme development for human islet isolation: Five decades of progress or stagnation?
af: Brandhorst, D, et al.
Udgivet: (2017)

Expression of complement regulatory proteins on islets of Langerhans: a comparison between human islets and islets isolated from normal and hDAF transgenic pigs.
af: Bennet, W, et al.
Udgivet: (2001)

Induction and amelioration of environmental stress in isolated islets until transplantation
af: Brandhorst, D, et al.
Udgivet: (2006)

Human islet separation utilizing a closed automated purification system.
af: Friberg, A, et al.
Udgivet: (2008)

New class of oxygen carriers improves islet isolation from long-term stored rat pancreata.
af: Brandhorst, H, et al.
Udgivet: (2008)

Isolation and Culture of the Islets of Langerhans from Mouse Pancreas
af: Kate Graham, et al.
Udgivet: (2016-06-01)

Degraded collagenase deteriorates islet viability.
af: Brandhorst, H, et al.
Udgivet: (2008)

Strategies to improve the oxygen supply to microencapsulated islets
af: Brandhorst, D, et al.
Udgivet: (2019)

Prevention of early islet graft failure by selective inducible nitric oxide synthase inhibitors after pig to nude rat intraportal islet transplantation.
af: Brandhorst, D, et al.
Udgivet: (2001)

The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors
af: Brandhorst, D, et al.
Udgivet: (2022)

No beneficial effect of two-layer storage compared with UW-storage on human islet isolation and transplantation.
af: Caballero-Corbalán, J, et al.
Udgivet: (2007)

The importance of tryptic-like activity in purified enzyme blends for efficient islet isolation.
af: Brandhorst, H, et al.
Udgivet: (2009)

High seeding density induces local hypoxia and triggers a proinflammatory response in isolated human islets
af: Brandhorst, D, et al.
Udgivet: (2016)

Heat-exposed pig islets are protected from inflammatory mediators but express proapoptotic proteins.
af: Brandhorst, D, et al.
Udgivet: (2003)

Influence of neutral protease activity on human islet isolation outcome.
af: Brandhorst, H, et al.
Udgivet: (2005)

Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation
af: Brandhorst, D, et al.
Udgivet: (2021)

Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets.
af: Brandhorst, D, et al.
Udgivet: (2013)

Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets
af: Brandhorst, D, et al.
Udgivet: (2013)

High-dosed nicotinamide decreases early graft failure after pig to nude rat intraportal islet transplantation.
af: Brandhorst, D, et al.
Udgivet: (2002)