Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.

ASPP1 and ASPP2 are activators of p53-dependent apoptosis, whereas iASPP is an inhibitor of p53. Binding assays showed differential binding for C-terminal domains of iASPP and ASPP2 to the core domains of p53 family members p53, p63, and p73. We also determined a high-resolution crystal structure fo...

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Bibliographic Details
Main Authors: Robinson, R, Lu, X, Jones, E, Siebold, C
Format: Journal article
Language:English
Published: 2008