Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways.

Antigen-specific T cell unresponsiveness in cloned helper T cells mediated via the CD2 or CD3/Ti receptor pathways.

We have investigated the role of the CD2 protein in the negative regulation of immune function and report that similar to antigen and anti-CD3, the monoclonal anti-CD2 antibodies (T112 and T113) can induce specific unresponsiveness. Antigen and anti-CD2 tolerogenic signals both down-regulated the ph...

Full description

Bibliographic Details
Main Authors:	Lamb, JR, Zanders, E, Sewell, W, Crumpton, M, Feldmann, M, Owen, M
Format:	Journal article
Language:	English
Published:	1987

Similar Items

Influence of antigen structure on the activation and induction of unresponsiveness in cloned human T lymphocytes.
by: Lamb, JR, et al.
Published: (1986)

Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.
by: Essery, G, et al.
Published: (1988)

T helper cell unresponsiveness: rapid induction in antigen-transgenic and reversion in non-transgenic mice.
by: Bachmann, M, et al.
Published: (1994)

Tolerance of T-cell clones is associated with membrane antigen changes.
by: Zanders, E, et al.
Published: (1983)

Tolerance in T-cell clones.
by: Feldmann, M, et al.
Published: (1985)

Heterogeneity of accessory cells interacting with T-helper clones.
by: Katz, DR, et al.
Published: (1986)

A human suppressor T cell clone which recognizes an autologous helper T cell clone.
by: Lamb, JR, et al.
Published: (1982)

T-cell clone anti-clone interactions. Effects on suppressor and helper activities.
by: Naor, D, et al.
Published: (1989)

Genetically restricted and unrestricted antigen specific helper factors
by: Feldmann, M, et al.
Published: (1982)

Enrichment of antigen-specific helper and suppressor T cells.
by: Maoz, A, et al.
Published: (1976)

Biochemical events initiated by exposure of human T lymphocyte clones to immunogenic and tolerogenic concentrations of antigen.
by: Zanders, E, et al.
Published: (1985)

The role of macrophages in the generation of T-helper cells. II. The genetic control of the macrophage-T-cell interaction for helper cell induction with soluble antigens.
by: Erb, P, et al.
Published: (1975)

Human alpha beta T-cell receptor CD4-CD8 T-cell clones are predominantly Th0-like.
by: Katsikis, P, et al.
Published: (1995)

Antigen-specific and non-specific helper activities derived from supernatants of human influenza virus-specific T-cell lines.
by: Zanders, E, et al.
Published: (1983)

Direct evaluation of antigen binding to human T lymphocyte clones: involvement of major histocompatibility complex products in antigen binding.
by: Zanders, E, et al.
Published: (1984)

Specific interactions between a human CD4+ clone and autologous CD4+ bifunctional immunoregulatory clones.
by: Naor, D, et al.
Published: (1990)

Antigen-specific helper factor reacts with antibodies to human beta 2 microglobulin.
by: Lamb, JR, et al.
Published: (1981)

The dissociation of interleukin-2 production and antigen-specific helper activity by clonal analysis.
by: Lamb, JR, et al.
Published: (1983)

In vitro studies on H-2-linked unresponsiveness to synthetic polypeptides. III. Production of an antigen-specific T helper cell factor to (T,G)-A--L.
by: Howie, S, et al.
Published: (1977)

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T-cells
by: Saliba, D, et al.
Published: (2019)

Human T cell clones present antigen.
by: Hewitt, C, et al.
Published: (1989)

Antigen-dependent and antigen-independent pathways modulate CD4+CD28null T-cells during atherosclerosis.
by: Ammirati, E, et al.
Published: (2012)

Antigen-sensitive CD8 T-cell clones with tough HIV-1 suppression
by: Glanville, J, et al.
Published: (2013)

The antigen dose determines T helper subset development by regulation of CD40 ligand.
by: Ruedl, C, et al.
Published: (2000)

In vitro studies on H-2 linked unresponsiveness. 1. Normal helper cells to (T,G)-A-L and GAT in low and non-responder mice.
by: Howie, S, et al.
Published: (1977)

INVITRO STUDIES ON H-2 LINKED UNRESPONSIVENESS .1. NORMAL HELPER CELLS TO (T,G)-A-L AND GAT IN LOW AND NON-RESPONDER MICE
by: Howie, S, et al.
Published: (1977)

Different Ly antigen phenotypes of in vitro induced helper and suppressor cells.
by: Feldmann, M, et al.
Published: (1975)

Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key.
by: Bachmann, M, et al.
Published: (2004)

Differences in the regulation of CD4 and CD8 T-cell clones during immune responses.
by: Beverley, P, et al.
Published: (2000)

Quantitative contribution of CD4 and CD8 to T cell antigen receptor serial triggering.
by: Viola, A, et al.
Published: (1997)

T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2.
by: Bensussan, A, et al.
Published: (1984)

CD4+ T follicular helper cells in human tonsils and blood are clonally convergent but divergent from non-Tfh cd4+ cells
by: Brenna, E, et al.
Published: (2020)

Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway.
by: Cornall, R, et al.
Published: (1999)

Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells.
by: Londei, M, et al.
Published: (1984)

Induction of specific helper cells in vitro.
by: Kontianen, S, et al.
Published: (1973)

Conditions for inducing T helper cells in vitro.
by: Kontiainen, S, et al.
Published: (1975)

Differentiation and activation antigens on CD8 T cells
by: Mongkolsapaya, J, et al.
Published: (1996)

The role of macrophages in the generation of T-helper cells. I. The requirement for macrophages in helper cell induction and characteristics of the macrophage-T cell interaction.
by: Erb, P, et al.
Published: (1975)

The role of macrophages in the generation of T helper cells. III. Influence of macrophage-derived factors in helper cell induction.
by: Erb, P, et al.
Published: (1975)

CD3Ti+ human thymocyte-derived clones displaying a differential response to activation via CD3Ti and CD2.
by: Testi, R, et al.
Published: (1989)