Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.

Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.

Histone N(ε)-methyl lysine demethylases KDM2/7 have been identified as potential targets for cancer therapies. On the basis of the crystal structure of KDM7B, we designed and prepared a series of hydroxamate analogues bearing an alkyl chain. Enzyme assays revealed that compound 9 potently inhibits K...

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Bibliographic Details
Main Authors: Suzuki, T, Ozasa, H, Itoh, Y, Zhan, P, Sawada, H, Mino, K, Walport, L, Ohkubo, R, Kawamura, A, Yonezawa, M, Tsukada, Y, Tumber, A, Nakagawa, H, Hasegawa, M, Sasaki, R, Mizukami, T, Schofield, C, Miyata, N
Format: Journal article
Language:English
Published: 2013

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