Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid

Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid

Butane-2,3-diacetal (BDA) desymmetrised glycolic acid building block 1 undergoes highly diastereoselective lithium enolate ketone aldol reactions with a range of methyl and mono-substituted methyl ketones to yield, after acid-catalysed deprotection, enantiopure α,β-dihydroxy acid derivatives bearing...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Dixon, D, Guarna, A, Ley, S, Polara, A, Rodriguez, F
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2002

समान संसाधन

Highly diastereoselective lithium enolate aldol reactions of butane-2,3-diacetal desymmetrized glycolic acid and deprotection to enantiopure anti-2,3-dihydroxy esters.
द्वारा: Dixon, D, और अन्य
प्रकाशित: (2001)

Studies on the generation of enolate anions from butane-2,3-diacetal protected glycolic acid derivatives and subsequent highly diastereoselective coupling reactions with aldehydes and acid chlorides
द्वारा: Ley, S, और अन्य
प्रकाशित: (2004)

Studies on the generation of enolate anions from butane-2,3-diacetal protected glycolic acid derivatives and subsequent highly diastereoselective coupling reactions with aldehydes and acid chlorides.
द्वारा: Ley, S, और अन्य
प्रकाशित: (2004)

Michael, Michael-aldol and Michael-Michael reactions of enolate equivalents of butane-2,3-diacetal protected glycolic acid derivatives.
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प्रकाशित: (2005)

Highly diastereoselective Michael addition reactions of butane-2,3-diacetal desymmetrized glycolic acid. Preparation of alpha-hydroxy-gamma-amino acid derivatives.
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A general and efficient procedure for the preparation of enantiopure anti-1,2-diols - synthesis and utility of (R ',R ',S,R)-2,3-butane diacetal protected butane tetrol
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Rapid assembly of anti,anti-1,2,3-triol motifs via stereoselective addition of organometallics to aldehydes obtained from (R ',R ',S,R)-2,3-butane diacetal protected butanetetraol derivatives
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Consecutive Three- and Four-Component Coupling Reactions with Anions Generated from a Butane Diacetal Desymmetrized Glycolic Acid Derivative We gratefully acknowledge financial support from the EPSRC (to D.J.D.), the EU (Marie Curie Fellowship to F.R.), and the Novartis Research Fellowship (to S.V.L.). We are also indebted to Dr. John E. Davis for the X-ray crystal structure determinations.
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