GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.

Thymocyte-expressed molecule involved in selection (THEMIS) is a recently identified regulator of thymocyte positive selection. THEMIS's mechanism of action is unknown, and whether it has a role in TCR-proximal signaling is controversial. In this article, we show that THEMIS and the adapter mol...

Full description

Bibliographic Details
Main Authors: Paster, W, Brockmeyer, C, Fu, G, Simister, P, de Wet, B, Martinez-Riaño, A, Hoerter, J, Feller, S, Wülfing, C, Gascoigne, N, Acuto, O
Format: Journal article
Language:English
Published: 2013