Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes and molecular mechanisms that are often specific to cell type. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association st...

Podrobná bibliografie
Hlavní autoři:	Suzuki, K, Hatzikotoulas, K, Southam, L, Bragg, F, Lin, K, Chen, Z, Millwood, I, Walters, R, Lindgren, C, Sun, M, McCarthy, M, Mahajan, A
Médium:	Journal article
Jazyk:	English
Vydáno:	Springer Nature 2024

Podobné jednotky

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Autor: Suzuki, Ken, a další
Vydáno: (2024)

Mechanisms of disease: genetic insights into the etiology of type 2 diabetes and obesity.
Autor: Lindgren, C, a další
Vydáno: (2008)

Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank
Autor: Gan, W, a další
Vydáno: (2016)

The genetic and epigenetic basis of type 2 diabetes and obesity.
Autor: Drong, A, a další
Vydáno: (2012)

The genetic and epigenetic basis of type 2 diabetes and obesity
Autor: Drong, A, a další
Vydáno: (2012)

Identification of type 2 diabetes loci in 433,540 East Asian individuals
Autor: Spracklen, CN, a další
Vydáno: (2020)

Genetics of type 2 diabetes.
Autor: Owen, K, a další
Vydáno: (2007)

The value of genetic risk scores in precision medicine for diabetes
Autor: McCarthy, M, a další
Vydáno: (2018)

Genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adults
Autor: Gan, W, a další
Vydáno: (2019)

The genetics of type 2 diabetes.
Autor: Gloyn, A, a další
Vydáno: (2001)

Genetics of type 2 diabetes.
Autor: McCarthy, M, a další
Vydáno: (2006)

Association of vitamin D with risk of type 1 2 diabetes: a Mendelian 2 randomisation study in European and Chinese adults
Autor: Lu, L, a další
Vydáno: (2018)

The importance of global studies of the genetics of type 2 diabetes.
Autor: McCarthy, M
Vydáno: (2011)

Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer’s pathophysiology
Autor: Vijay K. Ramanan, a další
Vydáno: (2021-03-01)

Pathophysiology of diabetes.
Autor: Frayn, K, a další
Vydáno: (1976)

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Autor: Morris, A, a další
Vydáno: (2012)

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Autor: Morris, A, a další
Vydáno: (2012)

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
Autor: Morris, A, a další
Vydáno: (2012)

Type 2 diabetes: new genes, new understanding.
Autor: Prokopenko, I, a další
Vydáno: (2008)

Understanding the genetic complexity of puberty timing across the allele frequency spectrum
Autor: Kentistou, KA, a další
Vydáno: (2023)

Genetics: how the UKPDS contributed to determining the genetic landscape of Type 2 diabetes.
Autor: Gloyn, A, a další
Vydáno: (2008)

The genetics of type 2 diabetes and its clinical relevance.
Autor: Pal, A, a další
Vydáno: (2013)

Dissection of the pathophysiology of type 1 diabetes by genetic analysis.
Autor: Todd, J, a další
Vydáno: (1993)

Recent Developments in the Genetic and Genomic Basis of Type 2 Diabetes
Autor: Richards, H, a další
Vydáno: (2013)

The genetic architecture of type 2 diabetes
Autor: McCarthy, D, a další
Vydáno: (2016)

The Importance of Global Studies of the Genetics of Type 2 Diabetes
Autor: Mark I. McCarthy
Vydáno: (2011-04-01)

The genetic architecture of sporadic and multiple consecutive miscarriage
Autor: Laisk, T, a další
Vydáno: (2020)

Genetics of type 2 diabetes mellitus and obesity--a review.
Autor: Jafar-Mohammadi, B, a další
Vydáno: (2008)

Type 1 and type 2 diabetes-chalk and cheese?
Autor: Owen, K, a další
Vydáno: (2009)

Human genetics of obesity and type 2 diabetes mellitus: past, present, and future
Autor: Ingelsson, E, a další
Vydáno: (2018)

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data
Autor: Fernández-Tajes, J, a další
Vydáno: (2019)

Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes.
Autor: McCarthy, M
Vydáno: (2011)

A saturated map of common genetic variants associated with human height
Autor: Yengo, L, a další
Vydáno: (2022)

Analysis of overlapping genetic association in type 1 and type 2 diabetes
Autor: Inshaw, JRJ, a další
Vydáno: (2021)

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
Autor: Southam, L, a další
Vydáno: (2009)

APOBEC3 as a driver of genetic intratumor heterogeneity
Autor: Subramanian Venkatesan, a další
Vydáno: (2021-12-01)

Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus
Autor: B. Ortega-Contreras, a další
Vydáno: (2022-04-01)

Inflammatory mitochondrial nucleic acids as drivers of pathophysiology
Autor: Christian G. Peace, a další
Vydáno: (2023-09-01)

The genetics of type 2 diabetes
Autor: Lindgren, C, a další
Vydáno: (2001)

Fine-scale mapping of type 2 diabetes susceptibility loci by imputation and conditional analysis
Autor: Wiltshire, S, a další
Vydáno: (2010)