The potassium-chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport-independent mechanism.

K(+)-Cl(-) cotransporters (KCCs) play a fundamental role in epithelial cell function, both in the context of ionic homeostasis and also in cell morphology, cell division and locomotion. Unlike other ubiquitously expressed KCC isoforms, expression of KCC2 is widely considered to be restricted to neur...

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Bibliographic Details
Main Authors: Wei, W, Akerman, C, Newey, S, Pan, J, Clinch, N, Jacob, Y, Shen, MR, Wilkins, R, Ellory, J
Format: Journal article
Language:English
Published: 2011