Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies

Influenza A viruses cause seasonal epidemics and global pandemics, representing a considerable burden to healthcare systems. Central to the replication cycle of influenza viruses is the viral RNA-dependent RNA polymerase which transcribes and replicates the viral RNA genome. The polymerase undergoes...

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Bibliographic Details
Main Authors: Keown, J, Zhu, Z, Carrique, L, Fan, H, Walker, A, Serna Martin, I, Pardon, E, Steyaert, J, Fodor, E, Grimes, J
Format: Journal article
Language:English
Published: Springer Nature 2022