MiR-184 expression is regulated by AMPK in pancreatic islets

MiR-184 expression is regulated by AMPK in pancreatic islets

AMPK is a critical energy sensor and target for widely used antidiabetic drugs. In β-cells, elevated glucose concentrations lower AMPK activity, and the ablation of both catalytic subunits (βAMPKdKO mice) impairs insulin secretion in vivo and β-cell identity. MicroRNAs (miRNAs) are small RNAs that s...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Martinez-Sanchez, A, Nguyen-Tu, M, Cebola, I, Yavari, A, Marchetti, P, Piemonti, L, de Koning, E, Shapiro, A, Johnson, P, Sakamoto, K, Smith, D, Leclerc, I, Ashrafian, H, Ferrer, J, Rutter, G
Format: Journal article
Sprache:English
Veröffentlicht: Federation of American Society of Experimental Biology 2017

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