Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.
Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell death. In contrast, little is known about the consequences of antigen presentation for the antigen-presenting cell (APC). We have determined the outcome of major histocompat...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2004
|
| _version_ | 1797055665388126208 |
|---|---|
| author | Setterblad, N Blancheteau, V Delaguillaumie, A Michel, F Bécart, S Lombardi, G Acuto, O Charron, D Mooney, N |
| author_facet | Setterblad, N Blancheteau, V Delaguillaumie, A Michel, F Bécart, S Lombardi, G Acuto, O Charron, D Mooney, N |
| author_sort | Setterblad, N |
| collection | OXFORD |
| description | Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell death. In contrast, little is known about the consequences of antigen presentation for the antigen-presenting cell (APC). We have determined the outcome of major histocompatibility complex class II-restricted peptide presentation to a specific T cell. We demonstrate that specific T lymphocyte interaction with peptide-presenting APCs led to apoptosis in the APC population. In contrast, T lymphocyte interaction with nonpeptide-loaded APCs or APCs loaded with monosubstituted peptide failed to induce T lymphocyte secretion of interleukin-2 and APC apoptosis. Phosphatidylserine externalization and mitochondrial depolarization were used to evaluate APC apoptosis. Fas/Fas ligand interactions were not required, but cytoskeletal integrity and caspase activation were essential for APC apoptosis. Antigen presentation leading to T lymphocyte activation is therefore coordinated with apoptosis in the APC population and could provide a mechanism of immune response regulation by eliminating APCs, which have fulfilled their role as specific ligands for T lymphocyte activation. This pathway may have particular importance for APCs, which are not sensitive to death receptor-induced apoptosis. |
| first_indexed | 2024-03-06T19:13:01Z |
| format | Journal article |
| id | oxford-uuid:1768e5dd-76aa-4f70-93bf-c6824a2def3a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:13:01Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:1768e5dd-76aa-4f70-93bf-c6824a2def3a2022-03-26T10:37:02ZCognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1768e5dd-76aa-4f70-93bf-c6824a2def3aEnglishSymplectic Elements at Oxford2004Setterblad, NBlancheteau, VDelaguillaumie, AMichel, FBécart, SLombardi, GAcuto, OCharron, DMooney, NAntigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell death. In contrast, little is known about the consequences of antigen presentation for the antigen-presenting cell (APC). We have determined the outcome of major histocompatibility complex class II-restricted peptide presentation to a specific T cell. We demonstrate that specific T lymphocyte interaction with peptide-presenting APCs led to apoptosis in the APC population. In contrast, T lymphocyte interaction with nonpeptide-loaded APCs or APCs loaded with monosubstituted peptide failed to induce T lymphocyte secretion of interleukin-2 and APC apoptosis. Phosphatidylserine externalization and mitochondrial depolarization were used to evaluate APC apoptosis. Fas/Fas ligand interactions were not required, but cytoskeletal integrity and caspase activation were essential for APC apoptosis. Antigen presentation leading to T lymphocyte activation is therefore coordinated with apoptosis in the APC population and could provide a mechanism of immune response regulation by eliminating APCs, which have fulfilled their role as specific ligands for T lymphocyte activation. This pathway may have particular importance for APCs, which are not sensitive to death receptor-induced apoptosis. |
| spellingShingle | Setterblad, N Blancheteau, V Delaguillaumie, A Michel, F Bécart, S Lombardi, G Acuto, O Charron, D Mooney, N Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells. |
| title | Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells. |
| title_full | Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells. |
| title_fullStr | Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells. |
| title_full_unstemmed | Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells. |
| title_short | Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells. |
| title_sort | cognate mhc tcr interaction leads to apoptosis of antigen presenting cells |
| work_keys_str_mv | AT setterbladn cognatemhctcrinteractionleadstoapoptosisofantigenpresentingcells AT blancheteauv cognatemhctcrinteractionleadstoapoptosisofantigenpresentingcells AT delaguillaumiea cognatemhctcrinteractionleadstoapoptosisofantigenpresentingcells AT michelf cognatemhctcrinteractionleadstoapoptosisofantigenpresentingcells AT becarts cognatemhctcrinteractionleadstoapoptosisofantigenpresentingcells AT lombardig cognatemhctcrinteractionleadstoapoptosisofantigenpresentingcells AT acutoo cognatemhctcrinteractionleadstoapoptosisofantigenpresentingcells AT charrond cognatemhctcrinteractionleadstoapoptosisofantigenpresentingcells AT mooneyn cognatemhctcrinteractionleadstoapoptosisofantigenpresentingcells |