The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function

The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function

The mRNA N6-methyladenosine (m6A) modification has emerged as an essential regulator of normal and malignant hematopoiesis. Inactivation of the m6A mRNA reader YTHDF2, which recognizes m6A-modified transcripts to promote m6A-mRNA degradation, results in hematopoietic stem cell (HSC) expansion and co...

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Bibliographic Details
Main Authors: Mapperley, C, van de Lagemaat, LN, Lawson, H, Tavosanis, A, Paris, J, Campos, J, Wotherspoon, D, Durko, J, Sarapuu, A, Choe, J, Ivanova, I, Krause, DS, von Kriegsheim, A, Much, C, Morgan, M, Gregory, RI, Mead, AJ, O'Carroll, D, Kranc, KR
Format: Journal article
Language:English
Published: Rockefeller University Press 2020

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