Investigating the role of alternative polyadenylation in neuronal differentiation and neurodegeneration

Investigating the role of alternative polyadenylation in neuronal differentiation and neurodegeneration

<p>Over 70% of human genes can undergo alternative polyadenylation (APA), whereby they utilise different polyadenylation (poly(A)) sites found in the 3’UTR (3’UTR-APA) or in the upstream coding region of the gene (upstream-APA). The 3’UTR harbours regulatory cis-elements which can mediate the...

Bibliografski detalji
Glavni autor:	Patel, R
Daljnji autori:	Furger, A
Format:	Disertacija
Izdano:	2017

Slični predmeti

Investigating the effects of influenza virus on alternative cleavage and polyadenylation
od: Louey, A
Izdano: (2018)

Investigating the contribution of alternative polyadenylation to the regulation of gene expression
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Izdano: (2016)

Extensive alternative polyadenylation during zebrafish development
od: Ulitsky, Igor, i dr.
Izdano: (2013)

Alternative polyadenylation: less than meets the eye?
od: Neve, J, i dr.
Izdano: (2014)

Alternative cleavage and polyadenylation in human CD46
od: Ly, Phuong Thao
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hnRNPC regulates cancer-specific alternative cleavage and polyadenylation profiles
od: Fischl, H, i dr.
Izdano: (2019)

Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation
od: Samuels, TJ, i dr.
Izdano: (2020)

Roles for cytoplasmic polyadenylation in cell cycle regulation.
od: Read, R, i dr.
Izdano: (2002)

Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation
od: Hardy, J, i dr.
Izdano: (2016)

Subcellular RNA profiling links splicing and nuclear DICER1 to alternative cleavage and polyadenylation
od: Furger, A, i dr.
Izdano: (2015)

Human cleavage factor I (CFIm) and its role in alternative polyadenylation of pre-mRNA
od: Hardy, J
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Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration
od: Victor, Matheus B, i dr.
Izdano: (2023)

Cytoplasmic polyadenylation in S. pombe
od: Stevenson, A, i dr.
Izdano: (2005)

Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease
od: Patel, R, i dr.
Izdano: (2019)

Alternative polyadenylation expands the mRNA isoform repertoire of human CD46
od: Ly, Phuong Thao, i dr.
Izdano: (2017)

Bioinformatical and experimental analysis of gene expression regulation through RNAi and alternative polyadenylation
od: Schlackow, M
Izdano: (2014)

Bioinformatics investigations on multi-omics datasets of neurodegeneration
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Role of senataxin in R-loop-mediated neurodegeneration
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Cleavage and polyadenylation: Ending the message expands gene regulation
od: Neve, J, i dr.
Izdano: (2017)

Polyadenylation and beyond: emerging roles for noncanonical poly(A) polymerases.
od: Schmidt, M, i dr.
Izdano: (2010)

Orthomyxovirus replication, transcription, and polyadenylation.
od: Neumann, G, i dr.
Izdano: (2004)

A beginning to the biochemistry of polyadenylation.
od: Humphrey, T, i dr.
Izdano: (1988)

Widespread shortening of 3′UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
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Izdano: (2012)

Neurodegeneration in multiple sclerosis /
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Izdano: (2007)

Changes in alternative polyadenylation throughout the yeast metabolic cycle and during glucose starvation in Saccharomyces cerevisiae
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Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation.
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Izdano: (1992)

Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophages
od: Wilton, J, i dr.
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Transcriptional termination and coupled polyadenylation in vitro.
od: Yonaha, M, i dr.
Izdano: (2000)

Recruitment of a basal polyadenylation factor by the upstream sequence element of the human lamin B2 polyadenylation signal.
od: Brackenridge, S, i dr.
Izdano: (2000)

Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development.
od: Lin, A, i dr.
Izdano: (2009)

RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage
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Izdano: (2013)

Global role for polyadenylation-assisted nuclear RNA degradation in posttranscriptional gene silencing.
od: Wang, S, i dr.
Izdano: (2008)

Thalamic neurodegeneration in multiple sclerosis.
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The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration
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Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration
od: Welch, Gwyneth M, i dr.
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Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB)
od: Heinrich, Sven U., i dr.
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DNA Damage and Its Links to Neurodegeneration
od: Madabhushi, Ram, i dr.
Izdano: (2017)

Regulation of biochemical pathways involved in neurodegeneration
od: Pooler, Amy Melissa
Izdano: (2006)

A magnetic resonance approach to neurodegeneration
od: Chen, Yin-Ching Iris
Izdano: (2009)

Inflammation versus neurodegeneration: consequences for treatment.
od: Palace, J
Izdano: (2007)