Synthesis, affinity for complementary RNA and DNA, and enzymatic stability of Triazole-linked locked nucleic acids (t-LNAs)
Dinucleoside phosphoramidites containing a triazole internucleotide linkage flanked by locked nucleic acid (LNA) were synthesized and incorporated into oligonucleotides (ONs). ONs bearing both LNA and triazole at multiple sites were obtained and their biophysical properties including enzymatic stabi...
| Main Authors: | , , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
American Chemical Society
2018
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