Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

Intestinal homeostasis is underpinned by LGR5+ve crypt-base columnar stem cells (CBCs), but following injury, dedifferentiation results in the emergence of LGR5−ve regenerative stem cell populations (RSCs), characterized by fetal transcriptional profiles. Neoplasia hijacks regenerative signaling, so...

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Bibliographic Details
Main Authors:	Gil Vasquez, E, Nasreddin, N, Valbuena, G, Mulholland, E, Belnoue Davis, H, Eggington, H, Schenck, R, Wouters, V, Wirapati, P, Gilroy, K, Lannagan, T, Flanagan, D, Najumudeen, A, Omwenga, S, McCorrry, A, Easton, A, Koelzer, V, East, J, Morton, D, Trusolino, L, Maughan, T, Campbell, A, Loughrey, M, Dunne, P, Tsantoulis, P, Huels, D, Tejpar, S, Sansom, O, Leedham, S
Format:	Journal article
Language:	English
Published:	Cell Press 2022

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

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