Development of novel in vitro and in vivo models for determining primary events in HLRCC tumourigenesis
<p>Germline mutations of fumarate hydratase (FH), encoding an enzyme of the tricarboxylic acid (TCA) cycle, predispose affected individuals to hereditary leiomyomatosis and renal cell cancer (HLRCC). FH-deficient cells and tissues have been shown to accumulate fumarate, exhibit S-(2-succinyl)...
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| Format: | Thesis |
| Language: | English |
| Published: |
2012
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| Subjects: |