The regulation and inhibition of P-TEFb

The regulation and inhibition of P-TEFb

<p>Correct regulation of transcription is essential for maintaining a healthy cellular state. During transcription RNA polymerase II (Pol II) proceeds in a regulated manner through several transitions to ensure appropriate control of synthesis and enable correct processing of the pre-RNA. Shor...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Hole, A
Awduron Eraill:	Noble, M
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2011
Pynciau:	Molecular biophysics (biochemistry) Biochemistry

Eitemau Tebyg

Pushing the boundaries: molecular dynamics simulations of complex biological membranes
gan: Parton, D
Cyhoeddwyd: (2011)

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues
gan: Labro, A, et al.
Cyhoeddwyd: (2008)

Biophysical and magnetic resonance studies of membrane proteins
gan: Orwick, M, et al.
Cyhoeddwyd: (2011)

Molecular dynamics study of water and Na⁺ ions in models of the pore region of the nicotinic acetylcholine receptor
gan: Smith, G, et al.
Cyhoeddwyd: (1997)

Structural studies of a membrane embedded chloride channel from E.Coli, a prokaryotic homologue of ClC channels
gan: Bowler, M, et al.
Cyhoeddwyd: (2001)

Interactions of Neisseria meningitidis with the human immune system
gan: Harding, R
Cyhoeddwyd: (2015)

Biophysical studies of membrane protein structure and function
gan: Dijkman, P, et al.
Cyhoeddwyd: (2014)

Radiation damage in protein crystals examined under various conditions by different methods
gan: Garman, E, et al.
Cyhoeddwyd: (2009)

Determination of X-ray flux using silicon pin diodes
gan: Owen, R, et al.
Cyhoeddwyd: (2009)

Fluorescence studies of influenza RNA and RNA polymerase
gan: Tomescu, A
Cyhoeddwyd: (2014)

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families
gan: Marles-Wright, J
Cyhoeddwyd: (2005)

Structural studies of malaria proteins
gan: Mayer, C
Cyhoeddwyd: (2012)

Structural studies on determinants of receptor/ligand binding in the tumour necrosis factor and T cell receptor protein families
gan: Marles-Wright, J
Cyhoeddwyd: (2005)

Structural studies of cell adhesion and division
gan: Yates, LA
Cyhoeddwyd: (2012)

Temporary serine protease inhibition and the role of SPINK2 in human bone marrow
gan: Vincenza Barresi, et al.
Cyhoeddwyd: (2023-06-01)

The relationship between flagellar motor dynamics and the proton motive force
gan: Tipping, M, et al.
Cyhoeddwyd: (2011)

A biophysical study of the G protein coupled receptor neurotensin receptor 1
gan: Harding, PJ
Cyhoeddwyd: (2007)

Control of the unidirectional motor in Rhodobacter sphaeroides
gan: Brown, MT
Cyhoeddwyd: (2009)

Structural characterisation of the interaction between Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and their human ligands in severe malaria
gan: Ng, HK
Cyhoeddwyd: (2012)

Structural, biochemical and computational studies of TRP channel transmembrane domain modularity
gan: Hanson, S
Cyhoeddwyd: (2014)

Structure-function studies of the bacterial dsDNA translocase FtsK
gan: Graham, JE
Cyhoeddwyd: (2010)

Molecular and structural characterisation of the human Fibrillin-1 N-C terminal interaction
gan: Yadin, D
Cyhoeddwyd: (2013)

Ion channels: structure of a molecular brake
gan: Sansom, M
Cyhoeddwyd: (1999)

The dielectric properties of water within model transbilayer pores
gan: Sansom, M, et al.
Cyhoeddwyd: (1997)

The molecular basis for ER tubule formation
gan: Brady, J
Cyhoeddwyd: (2015)

Substrate recognition by the proteasome
gan: Boehringer, J
Cyhoeddwyd: (2011)

K+ channels: gating mechanisms and lipid interactions
gan: Schmidt, M
Cyhoeddwyd: (2013)

Computational studies of signalling at the cell membrane
gan: Lumb, CN
Cyhoeddwyd: (2012)

Studying marcomolecular transitions by NMR and computer simulations
gan: Stelzl, LS
Cyhoeddwyd: (2014)

Structure and dynamics of picornavirus capsids to inform vaccine design
gan: Kotecha, A
Cyhoeddwyd: (2014)

Mutational analysis of isoform selectivity and conformational equilibria in protein kinase inhibition
gan: Alexander, LT
Cyhoeddwyd: (2015)

Mechanisms of transcription regulation by full-length CREB
gan: Jeremie Gaudez
Cyhoeddwyd: (2023)

Mass Photometry of Membrane Proteins
gan: Olerinyova, A, et al.
Cyhoeddwyd: (2020)

The influence of environment: simulations of the influenza BM2 proton channel
gan: Rouse, S
Cyhoeddwyd: (2012)

Improving rapid affinity calculations for drug-protein interactions
gan: Ross, G
Cyhoeddwyd: (2013)

Structural studies of cell surface signalling molecules for neuronal guidance and connectivity
gan: Mitakidis, N
Cyhoeddwyd: (2013)

Molecular characterisation of bacterial proteins that interact with sulfur or nitrogen compounds
gan: Grabarczyk, D, et al.
Cyhoeddwyd: (2014)

Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands.
gan: Robert, P, et al.
Cyhoeddwyd: (2012)

Single-molecule imaging of electroporated chemotaxis proteins in live bacteria
gan: Di Paolo, D
Cyhoeddwyd: (2015)

Ion channels: a first view of K⁺ channels in atomic glory
gan: Sansom, M
Cyhoeddwyd: (1998)