Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation.

This study examines the use of multiple cross mapping (MCM) to reduce the interval for an ethanol response QTL on mouse chromosome 1. The phenotype is the acute locomotor response to a 1.5-g/kg i.p. dose of ethanol. The MCM panel consisted of the six unique intercrosses that can be obtained from the...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Hitzemann, R, Malmanger, B, Cooper, S, Coulombe, S, Reed, C, Demarest, K, Koyner, J, Cipp, L, Flint, J, Talbot, C, Rademacher, B, Buck, K, McCaughran, J
Format: Journal article
Sprache:English
Veröffentlicht: 2002