Opiates control ACTH through a noradrenergic mechanism.
The administration of 16 mg of naloxone to six normal male subjects produced a significant rise in plasma cortisol. Pre-treatment with the noradrenergic α1-antagonist, thymoxamine 0.2 mg/kg, blocked this rise. It is suggested that opiate inhibition of the pituitary-adrenal axis is mediated via a nor...
| Glavni autori: | , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
1982
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