Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.

Programmed death ligand-1 (PD-L1) interaction with PD-1 induces T cell exhaustion and is a therapeutic target to enhance immune responses against cancer and chronic infections. In murine bone marrow transplant models, PD-L1 expression on host target tissues reduces the incidence of graft-versus-host...

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Main Authors:	Saha, A, O'Connor, R, Thangavelu, G, Lovitch, S, Dandamudi, D, Wilson, C, Vincent, B, Tkachev, V, Pawlicki, J, Furlan, S, Kean, L, Aoyama, K, Taylor, P, Panoskaltsis-Mortari, A, Foncea, R, Ranganathan, P, Devine, S, Burrill, J, Guo, L, Sacristan, C, Snyder, N, Blair, I, Milone, M, Dustin, M, Riley, J, Bernlohr, D, Murphy, W, Fife, B, Munn, D, Miller, J, Serody, J, Freeman, G, Sharpe, A, Turka, L, Blazar, B
Format:	Journal article
Language:	English
Published:	American Society for Clinical Investigation 2016

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.

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