Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

Glucokinase (GCK) serves as the pancreatic glucose sensor. Heterozygous inactivating GCK mutations cause hyperglycemia, whereas activating mutations cause hypoglycemia. We studied the GCK V62M mutation identified in two families and co-segregating with hyperglycemia to understand how this mutation r...

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Bibliographic Details
Main Authors:	Gloyn, A, Odili, S, Zelent, D, Buettger, C, Castleden, H, Steele, A, Stride, A, Shiota, C, Magnuson, M, Lorini, R, d'Annunzio, G, Stanley, C, Kwagh, J, van Schaftingen, E, Veiga-da-Cunha, M, Barbetti, F, Dunten, P, Han, Y, Grimsby, J, Taub, R, Ellard, S, Hattersley, A, Matschinsky, F
Format:	Journal article
Language:	English
Published:	2005

Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

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