LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease.

LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease.

Classical Parkinson's disease (PD) is characterized by the appearance of Lewy bodies (LBs) in affected brain regions, showing mostly compact alpha-synuclein deposition, in contrast with punctate or granular deposition, hypothesized to represent early stages of aggregation. Leucine-rich repeat k...

Descripció completa

Dades bibliogràfiques
Autors principals:	Alegre-Abarrategui, J, Ansorge, O, Esiri, M, Wade-Martins, R
Format:	Journal article
Idioma:	English
Publicat:	2008

Ítems similars

Parkinson disease, LRRK2 and the endocytic-autophagic pathway.
per: Alegre-Abarrategui, J, et al.
Publicat: (2009)

Relationship of Apolipoprotein E to Parkinson's disease-related alpha-synuclein pathology
per: Parkkinen, L, et al.
Publicat: (2013)

Neuropathological stages of neuronal, astrocytic and oligodendrocytic alpha-synuclein pathology in Parkinson’s disease
per: Maria Otero-Jimenez, et al.
Publicat: (2025-02-01)

Alpha-synuclein oligomers: a new hope.
per: Bengoa-Vergniory, N, et al.
Publicat: (2017)

Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s Disease
per: Giulia Lamonaca, et al.
Publicat: (2020-04-01)

Alpha-synuclein proximity ligation assay (AS-PLA) in brain sections to probe for alpha-synuclein oligomers
per: Roberts, RF, et al.
Publicat: (2019)

Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models.
per: Sloan, M, et al.
Publicat: (2012)

Alpha-Synuclein Pathology and the Role of the Microbiota in Parkinson’s Disease
per: Emily Fitzgerald, et al.
Publicat: (2019-04-01)

Phosphatases of α-synuclein, LRRK2 and tau: important players in the phosphorylation-dependent pathology of Parkinsonism
per: Jean-Marc eTaymans, et al.
Publicat: (2014-11-01)

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.
per: Alegre-Abarrategui, J, et al.
Publicat: (2009)

Targeting alpha-synuclein as a therapy for Parkinson’s disease
per: Fields, CR, et al.
Publicat: (2019)

LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?
per: Darren M. O’Hara, et al.
Publicat: (2020-06-01)

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
per: Carroll Rutherford Fields, et al.
Publicat: (2019-12-01)

Alpha-synuclein pathology in the olfactory pathways of patients with dementia
per: Hubbard, P, et al.
Publicat: (2006)

Gastrointestinal Biopsies for the Diagnosis of Alpha-Synuclein Pathology in Parkinson’s Disease
per: Maria Graciela Cersosimo
Publicat: (2015-01-01)

Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease
per: Emily M. Rocha, et al.
Publicat: (2018-01-01)

Alpha-synuclein pathology in the olfactory pathways of dementia patients.
per: Hubbard, P, et al.
Publicat: (2007)

Epitope mapping of antibodies to alpha-synuclein in LRRK2 mutation carriers, idiopathic Parkinson disease patients and healthy controls.
per: Beatriz eAlvarez-Castelao, et al.
Publicat: (2014-07-01)

Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease
per: Ruffmann, C, et al.
Publicat: (2018)

Pathological Functions of LRRK2 in Parkinson’s Disease
per: Ga Ram Jeong, et al.
Publicat: (2020-11-01)

An impedimetric assay of alpha-synuclein autoantibodies in early stage Parkinson's disease
per: Xu, Q, et al.
Publicat: (2014)

Mapping networks of alpha-Synuclein proteostasis in cellular models of Parkinson's disease pathology
per: Lewin, R
Publicat: (2020)

Pathological Pathways and Alpha-Synuclein in Parkinson's Disease: A View from the Periphery
per: Milo Jarno Basellini, et al.
Publicat: (2023-02-01)

Hypoxia and Alpha-Synuclein: Inextricable Link Underlying the Pathologic Progression of Parkinson's Disease
per: Mengyuan Guo, et al.
Publicat: (2022-07-01)

Association of MAPT (tau) haplotype with the pathology of Parkinson's disease
per: Parkkinen, L, et al.
Publicat: (2013)

Alpha-Synuclein spreading in Parkinson disease
per: Ariadna eRecasens, et al.
Publicat: (2014-12-01)

Alpha-Synuclein Aggregation in Parkinson's Disease
per: E. Srinivasan, et al.
Publicat: (2021-10-01)

α‐synuclein RT‐QuIC in cerebrospinal fluid of LRRK2‐linked Parkinson's disease
per: Alicia Garrido, et al.
Publicat: (2019-06-01)

Brainstem neuromelanin and iron MRI reveals a precise signature for idiopathic and LRRK2 Parkinson’s disease
per: Martín Martínez, et al.
Publicat: (2023-04-01)

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain
per: Enquan Xu, et al.
Publicat: (2022-01-01)

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons
per: Michael X. Henderson, et al.
Publicat: (2018-05-01)

Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease
per: Hiroaki Sekiya, et al.
Publicat: (2022-09-01)

Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease
per: Haichen Niu, et al.
Publicat: (2018-09-01)

PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson’s Disease
per: Wen Li, et al.
Publicat: (2021-07-01)

The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein
per: Michael P. Nelson, et al.
Publicat: (2018-02-01)

Alpha-Synuclein and Cognitive Decline in Parkinson Disease
per: Tian-Sin Fan, et al.
Publicat: (2021-11-01)

Modeling Parkinson’s Disease With the Alpha-Synuclein Protein
per: Mónica Gómez-Benito, et al.
Publicat: (2020-04-01)

Alpha-synuclein as a biomarker of Parkinson’s disease
per: S. N. Pchelina
Publicat: (2017-02-01)

Physiological and pathological properties of alpha-synuclein.
per: Tofaris, G, et al.
Publicat: (2007)

Escherichia coli triggers α-synuclein pathology in the LRRK2 transgenic mouse model of PD
per: Dongxiao Liang, et al.
Publicat: (2023-12-01)