Restriction by SAMHD1 limits cGAS/STING-dependent innate and adaptive immune responses to HIV-1
SAMHD1 is a restriction factor for HIV-1 infection. . SAMHD1 mutations cause the autoinflammatory Aicardi-Goutières syndrome that is characterized by chronic type I interferon (IFN) secretion. We show that the spontaneous IFN response in SAMHD1-deficient cells and mice requires the cGAS/STING cytoso...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Published: |
Cell Press
2016
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