Restriction by SAMHD1 limits cGAS/STING-dependent innate and adaptive immune responses to HIV-1

Restriction by SAMHD1 limits cGAS/STING-dependent innate and adaptive immune responses to HIV-1

SAMHD1 is a restriction factor for HIV-1 infection. . SAMHD1 mutations cause the autoinflammatory Aicardi-Goutières syndrome that is characterized by chronic type I interferon (IFN) secretion. We show that the spontaneous IFN response in SAMHD1-deficient cells and mice requires the cGAS/STING cytoso...

Full description

Bibliographic Details
Main Authors:	Maelfait, J, Bridgeman, A, Benlahrech, A, Cursi, C, Rehwinkel, J
Format:	Journal article
Published:	Cell Press 2016

Similar Items

Keeping your armour intact: how HIV-1 evades detection by the innate immune system: HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS.
by: Maelfait, J, et al.
Published: (2014)

Keeping your armour intact: How HIV-1 evades detection by the innate immune system: HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS Prospects and Overviews J. Maelfait et al.
by: Maelfait, J, et al.
Published: (2014)

BRCA2 loss induces an innate immune response via activation of the cGAS-STING pathway
by: Reisländer, T
Published: (2019)

Investigating the effects of cGAS-STING-dependent innate immune responses in BRCA2-deficient cells
by: Trajanovska, T
Published: (2022)

SAMHD1-dependent retroviral control and escape in mice.
by: Rehwinkel, J, et al.
Published: (2013)

SAMHD1-dependent retroviral control and escape in mice
by: Rehwinkel, J, et al.
Published: (2013)

Investigating SAMHD1 restriction of HIV-1 in stem cell-derived macrophages
by: Warner, D
Published: (2020)

A G1‐like state allows HIV‐1 to bypass SAMHD1 restriction in macrophages
by: Mlcochova, P, et al.
Published: (2017)

cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity
by: Liu, H, et al.
Published: (2019)

Varicella-Zoster virus ORF9 Is an antagonist of the DNA sensor cGAS
by: Hertzog, J, et al.
Published: (2020)

Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
by: Hertzog, J, et al.
Published: (2022)

Inheritance, innovation, and adaptation of immune systems: Regulation of the Innate Immunity Sensor Stimulator of Interferon Genes (STING)
by: Liu, Bingxu
Published: (2023)

Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1
by: Prabakaran, T, et al.
Published: (2018)

Characterisation of SAMHD1's ancestral function
by: Davenne, T
Published: (2018)

Innate immunity in acute HIV-1 infection
by: Borrow, P
Published: (2011)

Innate immunity in acute HIV-1 infection.
by: Borrow, P
Published: (2011)

Mouse knockout models for HIV-1 restriction factors.
by: Rehwinkel, J
Published: (2014)

Mouse knockout models for HIV-1 restriction factors.
by: Rehwinkel, J
Published: (2014)

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.
by: Clifford, R, et al.
Published: (2014)

Innate immune responses in primary HIV-1 infection.
by: Borrow, P, et al.
Published: (2008)

SAMHD1, A Putative Tumour Suppressor, Is Recurrently Mutated in Chronic Lymphocytic Leukaemia, and Is Associated with Poor Risk Features
by: Clifford, R, et al.
Published: (2012)

The innate immune effector cell response against HIV-1
by: Smalls-Mantey, A
Published: (2013)

Activation of STING-dependent innate immune signaling by S-phase-specific DNA damage in breast cancer
by: Parkes, EE, et al.
Published: (2016)

Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING
by: Chin, Ko-Hsin, et al.
Published: (2013)

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.
by: Fiil, B, et al.
Published: (2013)

Innate immune responses in acute HIV-1 infection: protective or pathogenic?
by: Borrow, P, et al.
Published: (2013)

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis
by: Wing, P, et al.
Published: (2019)

The role of PTEN in innate and adaptive immunity
by: Taylor, H, et al.
Published: (2019)

Crossroads between innate and adaptive immunity /
by: Crossroads Between Innate and Adaptive Immunity Conference (1st : 2005 : Rhodes, Greece), et al.
Published: (2007)

Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis
by: Maelfait, J, et al.
Published: (2017)

Role of Subdominant B*2705-Restricted Epitopes in Immune Control of HIV-1
by: Payne, R, et al.
Published: (2008)

Widespread impact of HLA restriction on immune control and escape pathways of HIV-1.
by: Carlson, J, et al.
Published: (2012)

TAK1, more than just innate immunity
by: Dai, Liang, et al.
Published: (2013)

Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection
by: Adland, E, et al.
Published: (2020)

Innate immunity against HIV: a priority target for HIV prevention research.
by: Borrow, P, et al.
Published: (2010)

Macrophage receptors implicated in the "adaptive" form of innate immunity.
by: Bowdish, D, et al.
Published: (2007)

Innate and adaptive immune responses in chronic HCV infection
by: Dustin, L
Published: (2015)

An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection
by: Akram, K, et al.
Published: (2017)

A stronger innate immune response during hyperacute HIV-1 infection is associated with acute retroviral syndrome
by: Hassan, AS, et al.
Published: (2021)

Elucidation of the role of microRNA in innate immune response and adaptive immune response.
by: Chew, Chun Cheong.
Published: (2009)