Alkyne derivatives of SARS-CoV-2 main protease inhibitors including nirmatrelvir inhibit by reacting covalently with the nucleophilic cysteine

Nirmatrelvir (PF-07321332) is a nitrile-bearing small-molecule inhibitor that, in combination with ritonavir, is used to treat infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Nirmatrelvir interrupts the viral life cycle by inhibiting the SARS-CoV-2 main protease (Mpro), w...

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Bibliographic Details
Main Authors:	Brewitz, L, Dumjahn, L, Zhao, Y, Owen, CD, Laidlaw, SM, Malla, TR, Nguyen, D, Lukacik, P, Salah, E, Crawshaw, AD, Warren, AJ, Trincao, J, Strain-Damerell, C, Carroll, MW, Walsh, MA, Schofield, CJ
Format:	Journal article
Language:	English
Published:	American Chemical Society 2023

Alkyne derivatives of SARS-CoV-2 main protease inhibitors including nirmatrelvir inhibit by reacting covalently with the nucleophilic cysteine

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