Drug oxidation by Cytochrome P450BM3: metabolite synthesis and discovering new P450 reaction types

There is intense interest in late‐stage catalytic CH bond functionalization as an integral part of synthesis. Effective catalysts must have a broad substrate range and tolerate diverse functional groups. Drug molecules provide a good test of these attributes of a catalyst. A library of P450BM3 muta...

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Autori principali: Ren, X, Yorke, J, Taylor, E, Zhang, T, Zhou, W, Wong, L
Natura: Journal article
Lingua:English
Pubblicazione: Wiley 2015