Statistical alignment: computational properties, homology testing and goodness-of-fit.

The model of insertions and deletions in biological sequences, first formulated by Thorne, Kishino, and Felsenstein in 1991 (the TKF91 model), provides a basis for performing alignment within a statistical framework. Here we investigate this model.Firstly, we show how to accelerate the statistical a...

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Bibliographic Details
Main Authors: Hein, J, Wiuf, C, Knudsen, B, Møller, M, Wibling, G
Format: Journal article
Language:English
Published: 2000