Effects of cell cycle variability on lineage and population measurements of messenger RNA abundance

Many models of gene expression do not explicitly incorporate a cell cycle description. Here, we derive a theory describing how messenger RNA (mRNA) fluctuations for constitutive and bursty gene expression are influenced by stochasticity in the duration of the cell cycle and the timing of DNA replica...

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Detalhes bibliográficos
Main Authors: Perez-Carrasco, R, Beentjes, C, Grima, R
Formato: Journal article
Idioma:English
Publicado em: Royal Society 2020