HSV-1 ICP22 is a selective viral repressor of cellular RNA polymerase II-mediated transcription elongation
The Herpes Simplex Virus (HSV-1) immediate-early protein ICP22 interacts with cellular proteins to inhibit host cell gene expression and promote viral gene expression. ICP22 inhibits phosphorylation of Ser2 of the RNA polymerase II (pol II) carboxyl-terminal domain (CTD) and productive elongation of...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2021
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